KMID : 1129720040210010061
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Korean Journal of Acupuncture 2004 Volume.21 No. 1 p.61 ~ p.77
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The Effects of ASARI HERBA CUM RADICE (AHCR) herbal acupuncture at St36 on ovalbumin-induced asthma in C57BL mouse
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Kim Il-Gu
Kim Young-Il Hong Kwon-Eui Yim Yun-Kyoung Lee Hyun Lee Byung-Ryul
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Abstract
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Objectives and methods : The aim of this study was to investigate the effect of AHCR(ASARI HERBA CUM RADICE) herbal acupuncture at St36 on ovalbumin-induced asthma in mice. C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week). Two experimental groups were treated with different concentrations(1%, 0.1%) of AHCR-HAS at Chok-samni (St36) for the later 8 weeks (3times/week).
Results : 1. Lung weight of the mice group treated with AHCR-HA decreased significantly compared with that of control group. 2. Total Leukocytes in BALF of the mice group treated wtih AHCR-HA decreased significantly compared with those of control group. 3. The number of Eosinophils in BALF of the mice group treated wtih AHCR-HA decreased significantly compared with that of control group. 4. The number of Gr-1+/CD11b+, CCR3+, CD4+, CD3e+/CD69+, IgE+/B220+ cells in the lungs of the mice group treated with AHCR-HA decreased significantly compared with that of control group. 5. The number of CD8+ cells in the lungs of the mice group treated with AHCR-HA didn¡¯t show significant difference compared with that of control group. 6. The concentration of IgE, IL-13, IL-4 in serum of the mice group treated with AHCR-HA decreased significantly compared with that of control group.
Conclusion : We conclude that AHCR-HA is effective on OVA-induced asthma in C57BL/6 mouse.
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KEYWORD
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OVA-induced asthma, AHCR(ASARI HERBA CUM RADICE, HA(herbal acupuncture)
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